NDR would like to congratulate Dr. Susanne Petri and her research team on their recent paper Altered Immunomodulatory Responses in the CX3ClL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1G93A Model of ALS. The paper was published in November in Biomedicines 2022 and examines the effects of human mesenchymal stem/stromal cell (hMSC)-based therapy on motor neuron survival. This work provides important information in in vitro analysis of the effects of human mesenchymal stem/stromal cell-based therapy on motor neuron survival and the effects on gene expression of growth factors and cytokines/chemokines in motor neurons and hMSCs. They report a higher viability with motor neuron co-culture but no significant protection against STS-induced apoptosis. The authors concluded that there are potential limitations of the therapeutic efficacy of hMSCs in ALS due to cellular crosstalk resulting in increased pro-inflammatory rather than anti-inflammatory signaling. NDR is pleased to provide partial funding for this project.
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